Ryse: Son of Rome is set in an alternate version of Rome. The series depicts Marius Titus leading the defense of Rome against oncoming Celtic barbarians led by Boudica. Marius hands a small, nondescript sack to a subordinate with the instructions to display it from an elevated position, then helps secure the Roman emperor, Nero, in a private safe room. At the emperor's behest he begins to tell his story; the rest of the series is an extended flashback depicting Marius' story up to this point.