Dr. Moreau is the titular main antagonist in H. G. Wells's 1896 science fiction novel The Island of Doctor Moreau.
He is a brilliant surgeon forced to relocate to a deserted island when it was discovered that he was performing vivisection (live dissection) upon animals. His ultimate goal was to form animals into human beings. Moreau has also appeared in three film adaptations as well as making a guest appearance in the comic book League of Extraordinary Gentlemen.
Add actors/actresses and cast the roles/films/series that they were rumored, considered, offered, negotiated, auditioned, turned down, and/or originally casted before getting recasted. (Please double-check in research.)