FBI analyst Grace Ashcroft investigates mysterious deaths among survivors of the Raccoon City incident caused by lingering T-virus mutations known as Raccoon City Syndrome (RCS). She is assigned to inspect a victim discovered in the derelict Wrenwood Hotel, where her mother, Alyssa, was murdered eight years earlier. Inside the hotel, Grace recovers a data disk left by Alyssa. She is abducted by former Umbrella scientist Victor Gideon, who has been searching for her. DSO agent Leon Kennedy, who is suffering from RCS, separately investigates the deaths. He arrives and sees Victor, who infects nearby civilians with the T-virus, triggering a zombie outbreak that allows him to escape with Grace to the Rhodes Hill Chronic Care Center. Leon's handler, Sherry Birkin, helps track Victor's location.
