In November 2005, Harvardville Airport falls victim to a T-virus attack both from inside the terminal and a crashlanded airline plane. TerraSave worker Claire Redfield coincidentally runs into Senator Ron Davis, a vocal opponent of TerraSave, and they are forced to hide in the VIP lounge with Rani, niece of a TerraSave employee. By nightfall, the airport has been locked down by the local Special Response Team and the United States Army, aiding evacuated survivors. Officers Angela Miller and Greg Glenn are joined by federal agent Leon S. Kennedy. Claire's group is rescued; however, they are forced to leave the infected Greg. Trucks from pharmaceutical corporation WilPharma arrive to administer a T-virus vaccine they created, but are destroyed by explosives. Leon reveals that a terrorist has threatened to unleash the T-virus throughout the U.S. should government officials involved in its creation not be revealed by midnight.
Claire accompanies WilPharma Head Researcher Frederic Downing to their Harvardville research facility. Downing reveals plans to make a G-virus vaccine next, angering Claire because of its extreme danger. Excusing himself, Downing leaves Claire in his office. Claire informs Leon about what Downing told her and learns that he and Angela have found the house of her brother Curtis on fire. Downing phones Claire, warning her about a man who has activated a time bomb. Claire briefly spots Curtis in the building's central garden, only for the bomb to detonate.
