Ethan Winters was declared dead after the destruction of the mountain village in Romania… but death was never a clean exit for someone already rewritten by the Mold. Reactivated by remnants of his Megamycete physiology, Ethan goes into hiding and becomes a private investigator, but is forcibly recovered by the Bioterrorism Security Assessment Alliance (BSAA) when Chris finds out he's alive. His mission: track a new experimental virus strain known only as “Manus", developed by the remnants of The Connections, a shadow biotech syndicate still operating in the ruins of Umbrella’s legacy. But Ethan is not alone in the hunt. Ada Wong, operating under the orders of a secretive client organization, is tasked with retrieving the virus strand intact—no matter the cost, and Jake Muller, a mercenary with a personal vendetta against bioweapons and the corporations that create them, has been sent to destroy it at the source. Three operatives. Three agendas. One evolving nightmare. As each follows separate leads through collapsing research zones, quarantined cities, and underground bio-labs, they begin to realize the truth: it's not just a virus strain—it is a self-adapting organism designed to overwrite infected biology and rewrite cognition itself, turning victims into coordinated extensions of a single emerging intelligence. When a failed containment test unleashes a fully evolved Bio-Organic Weapon unlike anything the world has seen, survival becomes impossible alone. Forced into an uneasy alliance, Ethan, Ada, and Jake must navigate a world where trust is lethal, memories are unreliable, and the virus is learning how to think.
