In July 2017, Ethan Winters is drawn to a derelict plantation in Dulvey, Louisiana, by a message from his wife, Mia, who has been presumed dead since going missing in 2014. He finds Mia imprisoned in the basement of a derelict house, and frees her. She tries to lead them out, but suddenly becomes violent and attacks him, forcing him to kill her. After receiving a call from a woman named Zoe offering assistance, Ethan is attacked by a revived Mia, who cuts his left hand off with a chainsaw.
