On 24 December 2012, Jake Muller, son of late bio-terrorist Albert Wesker, flees local authorities during a bio-terrorist attack in Edonia. He partners with Division of Security Operations (DSO) agent and Raccoon City survivor Sherry Birkin (Eden Riegel) and learns that she is to extract him from the country to create a vaccine for the new C-virus. However, they are hunted by Ustanak, a hulking bio-weapon. Meanwhile, a Bio-terrorism Security Assessment Alliance (BSAA) strike team led by Chris Redfield and Piers Nivans is deployed to combat the infected local populace. However, they are attacked by the leader of Neo-Umbrella, who refers to herself as Ada Wong; she kills most of the BSAA members, using a device that injects them with the C-virus, turning them into monsters, except Chris and Piers. Chris goes into a self-imposed exile, afflicted with post-traumatic amnesia. Meanwhile, Sherry and Jake's extraction by the BSAA is sabotaged, forcing them to crash into the mountains. They are captured by "Ada" for six months.
