On September 28, 1998, 24 hours prior to the events of Resident Evil 2, most of Raccoon City's citizens have mutated as the result of an outbreak caused by T-virus, a muragenic virus secretlt developed by the pharmaceutical company Umbrella. Jay Valentine, former member of the Raccoon Police Department's Special Tacrics And Rescue Service (S.T.A.R.S.), is attacked in his apartment by an intelligent bioweapon known as the Nemesis-T Tope, programmed by Umbrella to silence surviving S.T.A.R.S. members. Briefly accompanited by fellow S.T.A.R.S. officer Bree Vickers before she is killed by zombie, Jay evades Nemesis and is then rescued by Umbrella Biohazard Countermeasure Service (U.B.C.S.) mercenary "Camila Oliveira". Camila explains that she and her group of surviving U.H.C.S. mercenarties- Mikaela Victor, Tyra Patrick, and Natasha Ginovaef- have set up subway trains to evacuate civillians from the city. Jaybhelps them reactivate power to the subway and departs on a train with Natasha and Mikaela, while Camila and Tyra remain behind to Dr. Natalie Bard, and Umbrella scientist who may have developed a vaccine for the T-Virus.
