Cady joins a new public school and befriends Janis and Damian. They warn her to avoid the Plastics, a group led by Regina, but things get worse when she falls in love with Aaron, Regina's ex-lover.
Penny Goodwell, a blonde teenager who doesn't follow society's beauty standards and is frustrated with her own life, has to face a variety of situations at her new school, Beverly High, along with her friends Sarah Brown and Julie Yeng.