The show revolves around the adventures of three kindergarten aged girls with superpowers: Blossom (pink), Bubbles (blue), and Buttercup (green). The plot of an episode is usually some humorous variation of standard superhero and tokusatsu shows, with the girls using their powers to defend their town from villains and giant monsters. In addition, the girls have to deal with the normal issues that young children face, such as sibling rivalries, loose teeth, personal hygiene, going to school, bed wetting, or dependence on a security blanket. Episodes often contain hidden references to older pop culture (especially noticeable in the episode "Meet the Beat Alls," which is an homage to the Beatles). The cartoon always tries to keep different ideas within each episode with some small tributes and parodies thrown in.
The show is set mainly in the city of Townsville, USA. Townsville is depicted as a major American city, with a cityscape consisting of several major skyscrapers. In his review of The Powerpuff Girls Movie, movie critic Bob Longino of The Atlanta Journal-Constitution said, "the intricate drawings emanate 1950s futuristic pizzazz like a David Hockney scenescape," and that the show is "one of the few American creations that is both gleeful pop culture and exquisite high art."
