Two years after the events of Obscure, Shannon and Kenny Matthews are now enrolled in the nearby Fallcreek University, while Stan Jones is making ends meet as a pizza boy. Stan and Kenny have to take medication to prevent the effects of the plant from infecting their bodies, while Shannon has been able to adapt to the changes. As the story begins, a new drug created from a strange flower is quickly spreading its influence over the University's populace. Soon enough, a small group of students (Corey Wilde, Mei Wang, Amy Brookes, and Sven Hansen) along with the Leafmore High survivors have to face a horde of mutants and stop the spread of the contagion before the situation becomes critical. The students meet a scientist, Richard James, who is immersed in the biology of scientific black spores, and aids the player several times.
