After he had Spectre's leader Ernst Stavro Blofeld arrested, James Bond left active service, and a new agent 007, Nomi, replaced him. Just as he was trying to build a happy new life with his newfound love Madeleine Swann, Spectre agents attacked them in Italy and they ended up separated. Five years later, Bond's CIA friend Felix Leiter enlists his help in the search for a missing Russian scientist. When it becomes apparent that the scientist was working on a deadly bio-technological weapon that has been stolen by Spectre then hijacked by another criminal group (and, worse, that said weapon was developed under the supervision of the chief of MI6, M herself), Bond must confront a threat the likes of which the world has never seen before, and it has connections to Madeleine's own past.