This story takes place shortly after the events of "Monster's Rising : Enter a New World." Echidna and her children have embarked on a crucial quest : to find the family patriarch, the all-powerful Typhon, who was feared even by the Olympian gods. Having heard of this, the Vatican's secret service, fighting against "the forces of darkness" since its foundation, sends a veritable army of fanatics to try to stop the family from awakening the most powerful of the Titans. Meanwhile, the mysterious Canadian multi-billionaire James Ikol launches an expedition to a remote corner of Greece, where the legendary Labyrinth of Daedalus is said to be located, and where a weapon capable of stopping Typhon and his family is rumored to lie. Also aware of this, the Vatican sent the best Monster Hunter in its service, the excellent cyborg fighter-assassin "Il Mostro Esecutore" to try and get them out of the way, but some of his convictions will be shaken by certain revelations appearing in this story. Whatever happens now, one thing is certain : the world can no longer ignore the oldest monster family that exist !