Sylvester and Tweety are the most famous cat and bird comedy duo, consisting of Sylvester J. Pussycat Sr. and Tweety Bird, created by Friz Freleng, best known for Looney Tunes and Merrie Melodies animated shorts of the 1950s and 1960s. They live in Granny Emma's apartment in San Francisco and go on mystery-solving adventures as detectives.