After the events of season 1, the world has rapidly begun to change, though not necessarily for the better.
The partnership and relationship between V, Victoria Crane and Lady Eleanor Cross will be tested upon finding a new threat in Elizabeth Bathory and her sisterhood of vampiresses. Her reputation developed so strongly that many formed a religious fanatacism about her.
The Cross Organization are prompted to came out of retirement because of this. Returning to hunting vampires and other supernatural threats in secret as always.
While the so-called Blood Countess plots her own bloody path towards the subjugation of humankind, Father Gabriel Anderson of the Iscariot still had some unfinished business with V.
The rivalry between the Cross Organization and the Vatican's Iscariot continues over their different ideologies and religious views.
What follows is a furious competition between The Cross Organization and The Iscariot, to decide which one is better at handling vampires.
Heroes and monsters alike is consumed by the dark threats that would tear the world asunder yet again, it becomes increasingly clear that this was only the beginning of the nightmare.