The Royal Order of Protestant Knights, known as The Cross Organization, exist to protect Great Britain from the supernatural who prey upon humans.
At the heart of Cross's arsenal is "V", an ancient and powerful vampire bound in servitude to Cross's leader, Lady Eleanor Cross, whose devotion to the Anglican Church and the Queen prompts her to justify using the undead as tools to combat the undead.
The same cannot be said of their rival, the fanatical Section XIII Iscariot of the Catholic Church: the Iscariot consider Cross little better than the monsters they hunt, despise the Anglicans of England, and have their own trump card: the paladin Father Gabriel Anderson, who is just as bloodthirsty and nigh-invincible as V.
Into this blood feud stumbles Victoria Crane, the lone survivor of a police squad slaughtered by vampires.
V offers her choice: death or becoming a vampire. Victoria, chooses the latter and lets V turn her; as a consequence, she goes to work for Cross alongside V.
But there's something new out there: a latest designer drugs that give humans vampiric abilities are being sold on the streets of London.
With a new wave of evil creatures rising, Cross must rely on its two most unlikely recruits: ancient master vampire V and the newly turned Victoria, but can even they stand in the face of such overwhelming odds?
