In the future, a Mad Scientist expelled by the scientific community decides to exact his revenge by unleashing a powerful strain of mutant plague into the city, one which spreads like wildfire turning most of the citizens into mutated monsters. It's up to two heroes immune to the plague, Ricky Jones and Johnny Hart, to stop the virus by travelling across mutant-infested slums, city streets, and the scientist's lab in multiple action-packed levels filled with mutant and mechanical foes.