In a plot somewhat similar to 1984's The Muppets Take Manhattan, the Muppets travel to New York to stage one last Muppet Show, one that, according to Kermit, "first, celebrates the history and lore of the Muppets, and second, panders to Muppet geeks like Walter and the nerds who run Muppet Wiki." Along the way, the Muppets reunite with several friends from their past, including several retired characters from The Muppet Show, several characters from Muppets Tonight, Kermit's old friends from Sam and Friends, the cast of The Jim Henson Hour, Kermit's childhood friends from Kermit's Swamp Years, the characters from Saturday Night Live's "Land of Gorch" segments, and even Scooter's twin sister Skeeter from Muppet Babies (in her first official appearance in puppet form, and as an adult).
Meanwhile, the original Muppet Show sign has gone missing, and it's up to a search party of Muppets (Kermit, Miss Piggy, Fozzie, Gonzo, Scooter, Rowlf, Walter, Rizzo, Animal, Pepe, Robin, Sweetums, Camilla, and Uncle Deadly) to find it before it's curtains up on the show. Will they find the sign in time?
