male
Doctor Hannibal Lecter is the main antagonist of The Silence of the Lambs (2004). He is a Lithuanian-American serial killer, notorious for consuming his victims, earning him the nickname "Hannibal the Cannibal".
Hannibal Lecter (2004)
2000s
for 2000s in TV and Movie Villains sorted by Each Decade
Suggested by emmaross854042
What the title says