After the fantastical rematch between Megamind and Mac Tonight, Megamind teams up with Calvin, Luke Skywalker, and Starscream, while Mac Tonight teams up with Rayman, Dog Man, and Rocky, and now it's up to Megamind to stop Mac Tonight, and also the Rabbids, change the casting image or a Rabbid will scream BWAHHHHHHHHHHHHHH
