After Megamind was crowned the new hero of Metro City, a sudden crime wave hits the city, orchestrated by an organization called the Doom Syndicate. The Doom Syndicate have broken into Megamind's secret lair and obtained samples of Megamind's and Metro Man's DNA along with Megamind's DNA tracking device. It's up to Megamind to hunt down the Doom Syndicate, stop the crime wave and find the missing pieces of the DNA Tracker to locate and battle against Blue Tighten.
