Peter Parker is faced with his biggest challenge yet, six different villains all have personal grudges with either Peter or Spider Man, they decide to form the Sinister Six to defeat him. Peter enlists the help of a young man with very similar powers to himself, the man being Miles Morales. They team up to take down the villains, in the end Peter has a heroic sacrifice to save New York, encouraging Miles to pick up the mantle of Spider Man.
