Following the events of Spider-Man: No Way Home, a small remnant of the Venom symbiote is left behind. Instead of finding a random host, it's quickly contained by S.W.O.R.D. and taken in for study.
Months later, Eddie Brock, a disgraced investigative journalist—fired from the Daily Bugle by J. Jonah Jameson after a story went horribly wrong—has hit rock bottom. In a desperate attempt to salvage his career, he infiltrates the biological research facility (secretly a S.W.O.R.D. front) where the symbiote escapes and violently bonds with him. What follows is a horrifying struggle for control, as Eddie and the ravenous creature learn to coexist to survive, and in the process, they uncover a threat that only their monstrous union can stop.