After the events of Eternals 2, the universe remains unstable. The Celestials forced the Eternals to make a decision on who should serve as the Celestial Madonna to carry out the "reshaping" of the universe in the form of a child. The Eternals chose Mantis.
Mantis, pregnant and weakened, appears on Earth at Star-Lord's side, after the Elders of the Universe were tasked by the Celestials to control her. She narrowly escapes.
Star-Lord, unaware of the true enemy he faces, assembles a team of Adam Warlock, Angela, Beta Ray Bill, Silver Surfer, Gamora, and Starhawk to stop the Elders. When the Elders reveal the full extent of the Celestials´ plan and the Eternals' involvement, Mantis faces the choice of either accepting her role as the Celestial Madonna or opposing the Celestials, which will determine the fate of the universe.
