One of AIM's experiments brings Godzilla, Kong, and other monsters called "Titans" to the Marvel Universe and start rampaging around the world. Marvel's mightiest heroes including the Avengers, the Guardians of the Galaxy, the Fantastic Four, the Defenders, the X-Men, & more, race to save the world from Godzilla & Kong's rampage and find the truth behind them. Dr. Doom & AIM have plans for the Titans and they bring a number of Marvel's dangerous villains to their cause.
