In an attempt for power across the cosmos, Doctor Doom, Loki and Magneto assemble villains from each corner of the universe as an army to help them conquer it, while Nick Fury and S.H.I.E.L.D. assemble Spider-Man, The Avengers, X-Men, Fantastic Four, Guardians of the Galaxy, The Defenders and other superheroes across the universe in order to stop them.
