Four astronauts have their lives changed forever, when they end up being hit by a cloud of cosmic radiation. Reed Richards (John Krasinski) now has the ability to stretch his body like elastic, his wife Sue Storm (Emily Blunt) now has the ability of invisibility, her foolish younger brother Johnny Storm (Dacre Montgomery) the out of control party animal becomes a living inferno, Ben Grimm (Dwayne Johnson) becomes the Thing, a man made out of solid rock, and Reed and Sue's children Franklin Richards (Iain Armitage) and Valeria Richards (Raegan Revord) have powers just as their parents have. But there is one problem, Reed's sponsor, and old friend Victor Von Doom (Nikolaj Coster-Waldau) has also been affected and with full power, and has now become an unstoppable freak of nature and a dangerous force from the cosmos has come to destroy them all which needs to be stopped, before it's too late.