Peter Parker has not had it well recently. He hasn't moved on from Gwen Stacy's death, and his friendship with Harry Osborn has been fractured due to Norman Osborn's death. Suddenly, all of those problems come to a head when Peter finds a substance that becomes his new Spider-Man costume. As new villains have come out of the woodwork, Spider-Man is ready to fight. But the greatest enemy may be...himself.