Taking place after the video game, "Marvel's Spider-Man 2," Peter Parker's old friend, Gwen Stacey, returns to New York from a research trip to work at Oscorp. Gwen hopes to get in touch again with MJ, because they used to play in a band back in high school. While helping Norman Osborn find a cure for Harry, Gwen accidentally gets bitten by a radioactive spider and develops spider abilities. While trying to adjust to her new powers and her new suit, "Spider-Gwen" fails to save a colleague (not Peter Parker) and finds herself framed for murder. With help from her friend, Gloria (who played keyboards in her band), and occasionally from the other Spider-People, Gwen sets out to find the real culprit and clear her name. There will be free-roaming in NYC, side missions, flashback missions, and stealth missions.