It's when you are create your own Marvel Universe different from Marvel Cinematic Universe, X-Men, Spider-Man, The Amazing Spider-Man, Sony's Spider-Man Universe like Venom and Morbius, and other official Marvel Movies.
What would happen if Marvel created a sitcom with all its characters? You can add actors that are already in the MCU or new actors for the role, as long as it makes sense. They should preferably be actors who could accept the role (even as a cameo) and who can do comedy.