On A-Day, five members of the Avengers — Captain America, Iron Man, Thor, Black Widow, and Hulk — celebrate the unveiling of a second headquarters in San Francisco and their own Helicarrier, the Chimera, powered by a Terrigen Crystal. However, the ceremony is interrupted by a terrorist attack led by Taskmaster, resulting in most of San Francisco and the Chimera being destroyed and Captain America's apparent death. In addition, the destruction of the Terrigen Crystal produces Terrigen Mist, turning countless people into Inhumans. Blamed for the tragedy, the Avengers disband.
Five years later, superheroes have been outlawed while a science-based organization called A.I.M., led by former Avengers scientist George Tarleton, takes their place in society, vowing to find a cure for what is dubbed the "Inhuman Disease". At her home in Jersey City, teenage Inhuman Kamala Khan discovers damaged video footage apparently revealing Tarleton locking Captain America in the reactor room before it exploded. She is soon contacted by 'Tiny Dancer', a member of the Resistance, who tells her that A.I.M. is on to her. She attempts to meet Tiny Dancer at Heroes Park, but is captured by A.I.M. scientist Monica Rappaccini and brought to Tarleton, who tries to convince her that A.I.M. wants to help her understand her Inhuman abilities. However, Kamala escapes and make her way to Utah to find the Resistance...
