I’m not sure what the story would be about, but I would use some elements of Spider-Man: into the spider verse as blueprints. Instead of Madam web being the protagonist, Anya Corazon is the new protagonist. Ezekiel Simms is no longer the villain and is now an ally. The main villain is now Morlun the eater of spider people. I also added other villainous spider people. And the sub plot of the Parker’s no longer exists.
