Rizzoli & Isles is an American crime drama television series starring Angie Harmon as Jane Rizzoli and Sasha Alexander as Maura Isles. Based on the series of Rizzoli & Isles novels by Tess Gerritsen, the plot follows Boston Homicide police detective Jane Rizzoli and Chief Medical Examiner Dr. Maura Isles combining their experiences and strikingly different personalities to solve cases.