In Lost Soul Gregory looks at the filming of The Island of Dr. Moreau, specifically the period during which director Richard Stanley spent on the project. Stanley was brought on to the project early but was fired only a few days after principal photography began and was replaced by John Frankenheimer. The documentary looks into Stanley's vision for the film, as he had spent years working on the movie's script and had intended for Bruce Willis to star as Edward Douglas, a role that was later given to David Thewlis. Lost Soulfeatures interviews with several people involved with the movie's production and focuses on various aspects of the film, including numerous changes to the script and the difficulties the cast and crew members had to deal with on the set.
