In the jungle, a creature of its own form moves around. Its legs are very strong and its venom is extremely poisonous. Not only the predators inhabiting the jungle, but also humans become its prey. A unit led by the experienced Markus Cole and Major Michael Roberts is dropped into enemy territory, where it is supposed to free several American soldiers from partisan captivity in the middle of the jungle. After a successful operation, however, the American soldiers, instead of their longed-for vacation by the sea, have to fight a much more mysterious and dangerous enemy. The jungle turns into a trap from which there is no escape, and the American heroes learn for the first time in their lives what fear is when they face a giant tarantula. The central scientist responsible for this creature is actually a philanthropist trying to prevent a future catastrophe with overpopulation. However, its artificial and heavily irradiated nutrition causes another big problem instead of solving it. Specifically, a thirty-meter arachnid that enjoys anything that comes under its jaws. Not only this commando, but also a stubborn village doctor and a well-read lab technician, joins the fight against the oversized eight-legged vermin. When the going gets tough, the old friend King Kong appears and helps in the fight with the Tarantula.