A former assassin, known simply as The Bride, wakes from a coma four years after her jealous ex-lover Bill attempts to murder her on her wedding day. Fueled by an insatiable desire for revenge, she vows to get even with every person who contributed to the loss of her unborn child, her entire wedding party, and four years of her life. Once she sets out to seek revenge on him, she first must make the other four members of the Deadly Viper Assassination Squad suffer.