Twenty-two hundred years after the disappearance of his father, Jake Collins lives in the infamous haunted house where he is destined as Kamen Rider Vampire Blood to fight life-draining monsters called Fangires, this very race his father fought years ago before his disappearance. Jake must also deal with Kamen Rider Holly Cross who is part of an organization seeking to destroy the Fangire menace, as well as the fangires own rider Kamen Rider Hellsing.
