In 2011, near Port St. Lucie, Florida, Jotaro Kujo's daughter Jolyne Cujoh is framed for murder and sent to prison. She works together with various allies, including a child born in prison named Emporio Alniño, to hunt down the person responsible for her framing: prison chaplain Enrico Pucci, a loyalist to Dio who seeks the creation of a new universe shaped to the late vampire's will.
