The series follows Jessie Prescott (Debby Ryan), a young woman from a small town with big dreams who, rebelling against her strict father, decides to leave the military base in Texas where she grew up and moves to New York City. She accepts a job as a nanny and moves into a multimillion-dollar penthouse on the Upper West Side with the wealthy Ross family which includes jet-setting parents Morgan and Christina Ross and their four rambunctious children: Emma, Luke, Ravi, and Zuri, along with the family pet, Mr. Kipling, a seven-foot Asian water monitor lizard, that was later revealed to be a female. With a whole new world of experiences open to her, Jessie embarks on new adventures in the big city as she grows to rely on the love and support of the children in her care. Assisting her are Bertram (Kevin Chamberlin), the family's lazy and sarcastic butler, and Tony (Chris Galya), the building's 20-year-old doorman.
