It's been nearly three years since Captain America's colossal battle with Red Skull devastated the city of New York. The loss of life and collateral damage left many feeling angry and helpless, including crime-fighting billionaire Tony Stark. Convinced that Captain America is now a threat to humanity, Iron Man embarks on a personal vendetta to end his reign on Earth, while the conniving Baron Zemo launches his own crusade against the Man Out of Time.