On Earth-22, Joker and Harley Quinn kill Jimmy Olsen, kidnap a pregnant Lois Lane, and steal a nuclear weapon, which they connect to a heart rate monitor surgically attached to Lois' heart. Upon hearing of Lois' capture, Batman calls in all Justice League members to find her. The Flash finds the Scarecrow dead in his lab and his supply of Fear Toxin missing, before being killed by a trap laid by Joker.
Lois’s husband, a panicked Superman eventually finds Joker and Harley hiding on a submarine, but is attacked by Doomsday upon confronting them, and proceeds to punch the monster into space. As the other heroes arrive and apprehend the Joker and Harley, Batman realizes that they have mixed the Fear Toxin with Kryptonite, and used it to make Superman hallucinate that he is fighting Doomsday; in reality, he has beaten Lois to death. Batman tries to warn Superman, but as he realizes what he did, it is too late; Lois' heartbeat stops, causing the nuke to detonate, destroying Metropolis and killing 11 million people.
Under Batman's interrogation, Joker reveals that he had grown tired of their losing battle and sought to try and corrupt Superman instead. Moments later, Superman crashes the interrogation. Acting out of grief and rage at the loss of his wife, unborn child and his city, Superman brutally kills Joker.
