Hulk, She-Hulk, Red Hulk, A-Bomb, and Skaar come together as the Agents of S.M.A.S.H. to tackle threats that no other superheroes can face. The Agents of S.M.A.S.H. have their base near the town of Vista Verde (where Bruce Banner first became Hulk) and often face various threats with a recurring one being from Hulk's archenemy Leader.