The story follows Agent 47, a genetically enhanced human clone who worked for the International Contract Agency (ICA) as an assassin. The former contract killer has retired and started a peaceful life at a church, but after his only friend, Reverend Emilio Vittorio, is kidnapped by unknown assailants, 47 resumes work for the ICA in hopes of tracking him down. The film includes several flashbacks experienced by Agent 47 after almost being killed on a failed mission. Agent 47 then tries to bring down the Franchise, a rival contract killing organization that is threatening his employers, the ICA, and seeking to obtain the same cloning technology that created 47. Meanwhile, a frame story presents 47's life and various contracts he carried out, as narrated by a former FBI director to a journalist.
