Following the events of Hitman: Codename 47, two men investigate the massacre left by Agent 47 at the facility of his creator, Dr. Ort-Meyer, in Romania. One of them recognizes the former assassin on video footage of the events, and decides that they must "hire" him. Meanwhile, 47, having retired after erasing all evidence of his existence, leads a new life as a humble gardener at a Sicilian church owned by the Reverend Emilio Vittorio. One day, after 47 attends confession to ask for forgiveness for his past, a group of unknown men arrive at the church and abduct Vittorio, leaving behind a ransom note demanding $500,000.
