Harley Quinn has ended her toxic relationship with the Joker and now that she is finally single, she decides to make a name for herself and become the head of her own criminal organisation. However as plans go south with a hopeless squad she had assembled she seeks help from her long time friend Poison Ivy. While Ivy helps Harley through her breakup with the Joker the two begin a romantic relationship aswell as becoming crime partners. Meanwhile, Catwoman has spent years in the vigilante game alone after ending any ties with Batman. Catwoman has teamed up and done business with varies villains across Gotham City. After breaking free of Arkham Asylum, Black Mask has returned to being a mob boss and doing undercover business through the city, while also beginning a partnership with Victor Zsasz. Sionis discovers the competition he now has he decides to put a target on each crime boss in Gotham and that includes Harley, Ivy and Catwoman.
