Catwoman and Harley Quinn, intending to kidnap a child, they don't know that the child is the son of Talia Al Ghul, the leader of the League of Assassins.
When they enter the child's house, they realize who the mother of the child is. But at the same time they witnessed the overthrow of Talia Al Ghul by her younger sister, Nyssa Ratko. Nyssa kill Talia's loyal bodyguard, Bane and and held Talia's son, Damian Wayne.
With terrible conditions, Catwoman and Harley Quinn save Talia to the places of Gotham City Sirens. After arguing, Harley Quinn, Poison Ivy, and Catwoman decided to help Talia Al Ghul to reclaim his position as League of Assassins Leaders.
But trouble comes, knowing Talia Al Ghul's condition their enemies like Black Mask try to attack them, including Batman and The Huntress. Also the Gotham City Police Department led by Commissioner Gordon and Renee Montoya who are also hunting them.
Nyssa Raatko send Lady Shiva and Deathstroke to make sure the death of Talia Al Ghul make their position even more threatened.
Harley Quinn and Poison Ivy try to find help, but only Katana and Zatanna is willing to help.
