Set 23 years after the end of Godzilla: The Series, lack of mutation activity starting with Godzilla's mysterious disappearance has made the members of organisation H.E.A.T. move on. Each member has gone their separate way, except for Nick Tatopoulos, who still continues his research at H.E.A.T. headquarters and teaches classes about mutations at Columbia University. When mutations start reappearing, Godzilla returns and Nick is forced to recruit his six students as the new H.E.A.T. members.
