After the events of Ghostbusters 3: Afterlife, Ghostbusters: Oklahoma, Ghostbusters: Spirits Unleashed, and Ghostbusters: Back In Town, the business is back, and with it, a new and improved team. But psychokinetic energy has been rising, because a sinister cult is planning to bring about the end of the world by having Hell invade our world. So when it comes to fighting the devil, who ya gonna call?