Gameoverse takes place in a universe of video game worlds; within the Gameoverse, if a world's hero successfully defeats its main villain and completes the game, that world proceeds to be annihilated. Two rival groups, the Farcade and the Syntax, struggle against each other to either prevent or facilitate this destruction, respectively. The series follows Kit, a Farcade agent who travels from world to world attempting to save them by helping each game's villains, while contending with the Syntax, who assist heroes to expedite their worlds' annihilation.