Abandoned by their father as kids, two young brothers try to resurrect their mother, who died from a terminal illness. To do this the brothers use alchemy - a science which allows the user to transform matter from one form to another. However, human transmutation is strictly forbidden and cannot be carried out successfully. The brothers experience this as the younger brother looses his entire bother, while the older brother only looses his leg for the transmutation of their mother and his arm for the retrieval of his brother's soul.
Determined to get their bodies back, Edward joins the military as a state alchemist and the brothers begin their search for the philosopher's stone. During their journey, they discover the truth about the country's history, and the conspiracy at the higher levels of the military and take it upon themselves to save the country's future.
